Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway

Figure 2

SFN-induced lymphoblastoid NRF2 ChIP-seq, ENCODE chromatin state annotation (ChromHMM), conservation, and ENCODE K562 NFE2 ChIP-seq tracks of NRF2-regulated known and novel target genes. ChromHMM legend shows 15 chromatin state annotations representing the relationship between chromatin state, function, and gene expression. Blue boxes display NRF2, NFE2, and conservation peaks. (a) Known NRF2-regulated HMOX1. (b–g) Novel NRF2-bound peak regions colocated with highly conserved ARE sequences and NFE2 ChIP-seq peaks in the (b) β-globin locus, (c) AMBP, (d) ABCB6, (e) FECH, (f) HRG1 (SLC48A1), and (g) TBXAS1 genes.