The Natural Stilbenoid Piceatannol Decreases Activity and Accelerates Apoptosis of Human Neutrophils: Involvement of Protein Kinase C

Table 1

Dose-dependent inhibition of neutrophil oxidative burst in the presence of piceatannol. Chemiluminescence, measured in whole blood, was initiated with PMA (0.05 μmol/L), Ca²⁺-ionophore A23187 (1 μmol/L), or opsonized zymosan (0.5 g/L). The incubation of neutrophils with piceatannol was 60 min (PMA, zymosan) or 30 min (A23187), depending on the kinetics of oxidative burst. Mean ± SEM, 𝑛=8, ^∗𝑃≤0.05, ^∗∗𝑃≤0.01  versus Control.

Piceatannol (μmol/L)	Inhibition of chemiluminescence (% of control)
	PMA	A23187	Zymosan
0.01	93.21±2.64^∗	96.74±1.41	98.10±1.10
0.1	84.45±1.99^∗∗	91.64±1.84^∗∗	98.63±1.42
1	41.19±2.19^∗∗	73.89±4.39^∗∗	93.22±1.98^∗
10	4.12±0.21^∗∗	19.40±3.30^∗∗	50.17±1.37^∗∗
100	0.25±0.04^∗∗	0.07±0.07^∗∗	0.26±0.07^∗∗