Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease

Figure 2

Possible mechanisms underpinning the beneficial effects of anthocyanins in NAFLD and NASH: a Srebp1c working model based on available studies. Anthocyanins may prevent the progression of liver damage related to NAFLD by three independent mechanisms: inhibition of lipogenesis by reducing Srebp1c, promotion of lipolysis by induction of PPARα activity, and reduction of oxidative stress by induction of anti-oxidant enzymes. The effects of anthocyanins on lipid metabolism seem to be dependent on the activation of the AMPK pathway in hepatocytes.