Oxidative Medicine and Cellular Longevity

Review Article

Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Table 2

New therapeutic approaches for DN. DRG: dorsal root ganglion neuron.
EndpointStudy populationsCompoundStudy
Improvement of peripheral nerve functionDiabetic ratsSalvianolic acid AYu et al. [79]
Improvement of DNAnimal model of T2DHigh-fat diet with menhaden oilCoppey et al. [80]
Improvement of DNPatients with T2D and neuropathyTai Chi exercise Ahn and Song [81]
Improvement of DNT2DM patientsBeraprost sodiumShin et al. [82]
Improvement of DNSTZ-diabetic ratsAnandamideSchreiber et al. [83]
Improvement of peripheral nerve functionMouse model of DPNThymosin β4Wang et al. [84]
Improvement of chronic pain, including PDNRat model of STZ-induced PDNGastrodinSun et al. [85]
Prevention of progression of DNPatients enrolled in the aldose reductase inhibitor-diabetes complicationsEpalrestatHotta et al. [86]
Improvement of DNSTZ-diabetic ratsGliclazide with curcuminAttia et al. [87]
Improvement of DNSTZ-diabetic ratsBone marrow-derived mononuclear cellsNaruse et al. [88]
Neuroprotection effectIn vitro model of high glucose-treated DRG neurons in cultureGalaninXu et al. [89]
Improvement of DN—Baicalein Yorek [90]
Improvement of neuropathic painAnimal models of neuropathic painBrazilian armed spider venom toxin Tx3-3Dalmolin et al., [91]
Neuroprotection effect
Improvement of DN		STZ-diabetic ratsMagnesium-25 carrying porphyrin-fullerene nanoparticlesHosseini et al. [92, 93]
Maintaining health in diabetesSTZ-diabetic ratsPhosphodiesterase inhibitorsMilani et al. [94]
Improve transplant outcome and graft function in diabetesIsolated rat pancreatic isletsIMODLarijani et al. [95]
Improve islet transplantation in diabetesIsolated rat pancreatic isletsCerium and yttrium oxide nanoparticles Hosseini and Abdollahi [96, 97]