The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

Table 1

The role of Nrf2 in adipocyte differentiation.

Adipogenesis and Nrf2	Suggested mechanism	Presented marker	Reference
Nrf2↓→adipogenesis↓	Regulation of adipogenic genes and adipogenesis downstream genes	PPAR𝛾, CEBP𝛼, aP2, CD36, LPL, and ADPSN	[15]
Nrf2↓→adipogenesis↓	Regulation of adipogenic genes	PPAR𝛾1, PPAR𝛾2, CEBP𝛽, Adipsin, and FABP4	[16]
Nrf2↑→adipogenesis↓	Regulation of adipogenic genes, Ahr and Ahr downstream genes	PPAR𝛾2, CEBP𝛼, CEBP𝛽, FABP4, Cyp1a1, Cyp1b1, and Gsta1	[19]
Nrf2↑→adipogenesis↓	Regulation of adipogenic genes, adipogenesis downstream genes, Ahr and Ahr downstream genes	PPAR𝛾, CEBP𝛼, CEBP𝛽, FABP4, FAS, SREBP1c, SCD-1, ACC-1, ACC-2. CD36, Cyp1b1, and Gsta1	[20]
Nrf2↑→adipogenesis↓	Induction of phase II enzymes and stimulation of GSH metabolism	Gsta2, Gclc, Abcc4, Abcc1, and GSH level	[22]
Nrf2↑→adipogenesis↔	Regulation of adipogenic genes	CEBP𝛼 and FABP4	[23]