The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

Table 2

The role of Nrf2 in obesity.

Obesity and Nrf2	Regulation of Nrf2	Reference
Nrf2↓→obesity↓	Nrf2 KO mice	[15]
Nrf2↑→obesity↓	Keap1-KD, Lep(ob/ob)-Keap1-KD mice	[20]
Nrf2↑→obesity↓; Nrf2↓→obesity↓	Nrf2 agonist: CDDO-Im; Nrf2 disrupted mice	[23]
Nrf2↓→obesity↓	Nrf2 KO mice	[34]
Nrf2↓→obesity↔	Nrf2-null mice, Keap1-KD mice	[35]
Nrf2↓→obesity↔	Myeloid Nrf2 KO mice	[36]
Nrf2↑→obesity↓	Nrf2 agonist: oltipraz	[27]
Nrf2↑→obesity↓	Nrf2 agonist: ellagic acid	[28]
Nrf2↑→obesity↓	Nrf2 agonist: quercetin	[29]
Nrf2↑→obesity↓	Nrf2 agonist: curcumin	[30, 31]
Nrf2↑→obesity↓	Nrf2 agonist: chromium histidinate	[32]
Nrf2↑→obesity↓	Nrf2 agonist: resveratrol	[33]