Senescence-Related Changes in Gene Expression of Peripheral Blood Mononuclear Cells from Octo/Nonagenarians Compared to Their Offspring

Table 3

Analysis of gene list (𝑃<0.05, FDR) by Fisher’s exact test.

Biological process	Source^a	List hits^b	Population hits^c	𝑃 value^d
Transcription	GO:0006355	113	2246	5.63𝐸−13
Translation	GO:0006412	40	635	1.08𝐸−07
Insulin action	GO:0046626	70	905	2.45𝐸−05
Cell cycle	GO:0007049	30	539	4.43𝐸−05
Cell division	GO:0051301	18	266	1.42𝐸−04
Response to stress	GO:0006950	16	239	3.67𝐸−04
Double-strand break repair	GO:0006302	5	30	8.14𝐸−04
Cell cycle arrest	GO:0007050	5	115	1.66𝐸−03
Regulation of apoptosis	GO:0006915	12	177	1.72𝐸−03
Chromatin modification	GO:0016568	12	186	2.60𝐸−03
Response to DNA damage stimulus	GO:0006974	14	236	2.60𝐸−03
Metabolic process	GO:0008152	35	858	3.38𝐸−03
Induction of apoptosis	GO:0006917	12	207	6.10𝐸−03
Immune response	GO:0006955	18	604	2.55𝐸−01
Inflammatory response	GO:0006954	10	293	2.00𝐸−01

aSource is from the Gene Ontology, http://www.geneontology.org/.
^bNumber of genes present in this set of 812 genes; 𝑃<0.05, FDR (list hits) (see Supplementary Table S2).
^cNumber of genes in each category present in the entire array (population hits).
^dThe 𝑃 value refers to Fisher’s exact test (see experimental procedures).