Senescence-Related Changes in Gene Expression of Peripheral Blood Mononuclear Cells from Octo/Nonagenarians Compared to Their Offspring
Table 3
Analysis of gene list (, FDR) by Fisher’s exact test.
Biological process
Sourcea
List hitsb
Population hitsc
valued
Transcription
GO:0006355
113
2246
Translation
GO:0006412
40
635
Insulin action
GO:0046626
70
905
Cell cycle
GO:0007049
30
539
Cell division
GO:0051301
18
266
Response to stress
GO:0006950
16
239
Double-strand break repair
GO:0006302
5
30
Cell cycle arrest
GO:0007050
5
115
Regulation of apoptosis
GO:0006915
12
177
Chromatin modification
GO:0016568
12
186
Response to DNA damage stimulus
GO:0006974
14
236
Metabolic process
GO:0008152
35
858
Induction of apoptosis
GO:0006917
12
207
Immune response
GO:0006955
18
604
Inflammatory response
GO:0006954
10
293
Source is from the Gene Ontology, http://www.geneontology.org/.
bNumber of genes present in this set of 812 genes; , FDR (list hits) (see Supplementary Table S2).
cNumber of genes in each category present in the entire array (population hits).
dThe value refers to Fisher’s exact test (see experimental procedures).