Senescence-Related Changes in Gene Expression of Peripheral Blood Mononuclear Cells from Octo/Nonagenarians Compared to Their Offspring
Table 4
Genes differentially expressed in PBMC of octo/nonagenariansa () versus offspring (). Statistical analysis was carried out with t-test. Genes were classified based on functional category.
Function
Gene symbol
Corrected valueb
valuec
Fold changed
Regulation
Gene name
Entrez IDe
Cell cycle
BAK1
1.52
Up
BCL2-antagonist/killer 1
NM_001188
CDKN1B
1.43
Up
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NM_004064
CDK3
1.31
Up
Cyclin-dependent kinase 3
NM_001113324
TRADD
1.48
Up
TNFRSF1A-associated via death domain
NM_003789
CASP2
1.33
Down
Caspase 2, apoptosis-related cysteine peptidase
NM_032982
CDC14A
1.53
Down
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
NM_003672
Immune and related function
CD40LG
1.46
Down
CD40 ligand (TNF superfamily, member 5, hyper-I gM syndrome)
NM_000074
CYSLTR2
1.62
Down
Cysteinyl leukotriene receptor 2
NM_020377
IL6ST
1.46
Down
Interleukin 6 signal transducer (gp130, oncostatin M receptor)
Telomeric repeat binding factor 2, interacting protein
NM_018975
TINF2
1.31
Up
TERF1 (TRF1)-interacting nuclear factor 2
NM_012461
XRCC6
1.27
Up
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70 kDa)
NM_001469
DICER1
1.28
Down
Dicer 1, ribonuclease type III
NM_177438
Translation and transcription
USF1
1.33
Up
Upstream transcription factor 1
NM_007122
KEAP1
1.23
Up
Kelch-like ECH-associated protein 1
NM_203500
NRF1
1.19
Up
Nuclear respiratory factor 1
NM_005011
SIRT7
1.18
Up
Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
NM_016538
Autophagy
BECN1
1.32
Up
Beclin 1, autophagy related
NM_003766
VPS18
1.26
Up
Vacuolar protein sorting 18 homolog (S. cerevisiae)
NM_020857
The genes shown in this table are ordered according to the biological processes. For a complete list of all 812 genes significantly affected in octo/nonagenarians, see Table S2.
bCorrected value refers to value after multiple testing corrections by Benjamini-Hochberg method.
cP value refers to value before multiple testing corrections by Benjamini-Hochberg method.
dThe fold change refers to the ratio of the expression values of octo/nonagenarians over offspring.
eSource of entrez ID is from National Center for Biotechnology Information (NCBI), http://www.ncbi.nlm.nih.gov/gene/.