Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 1

Determination of the lipid peroxidation levels in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg⁻¹.

Groups	TBARS (mmol min^−1 µg protein^−1)
	Hippocampus	Striatum	Frontal cortex	Cerebellum
Vehicle	1.36 ± 0.14	1.34 ± 0.06	1.54 ± 0.04	1.43 ± 0.06
5TIO1 0.1	0.13 ± 0.03^a	0.13 ± 0.01^a	0.12 ± 0.02^a	0.13 ± 0.03^a
5TIO1 1	0.16 ± 0.01^a	0.16 ± 0.01^a	0.15 ± 0.01^a	0.18 ± 0.03^a,b
5TIO1 10	0.15 ± 0.01^a	0.15 ± 0.02^a	0.15 ± 0.01^a	0.17 ± 0.03^a,b

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg⁻¹, 𝑛=7, 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline (𝑛=7, Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). ^a𝑃<0.05 compared to the control group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test); ^b𝑃<0.05 compared to the 5TIO1 0.1 group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test).