Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 2

Nitrite content in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg⁻¹.

Groups	Nitrite (µM)
	Hippocampus	Striatum	Frontal cortex	Cerebellum
Vehicle	95.86 ± 7.67	94.71 ± 3.35	76.57 ± 1.72	82.43 ± 1.99
5TIO1 0.1	5.11 ± 1.16^a	6.00 ± 1.82^a	6.49 ± 1.97^a	6.93 ± 2.25^a
5TIO1 1	6.36 ± 2.73^a	4.98 ± 1.51^a	6.19 ± 3.24^a	4.81 ± 1.43^a
5TIO1 10	7.14 ± 2.62^a	9.04 ± 6.54^a	8.50 ± 3.33^a	9.04 ± 4.76^a

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg⁻¹, 𝑛=7, 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline (𝑛=7, Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). ^a𝑃<0.05 compared to the control group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test).