Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3β Signaling

Figure 1

CO attenuates DSS-induced experimental colitis as measured by survival, body weight, and colon length. Mice were administrated with 3% DSS with drinking water for 6 days and CO (250 ppm) inhalation for 4 h daily and injection of LiCl (200 mg/kg, i.p) was performed daily for more 4 or 6 days. (a) Survival percent was measured at day 12. (b) Body weight was measured at day 10. (c) and (d) Colon length. (c) Representative images of 3 tests conducted in each group. (d) Data are mean ± SD for 3 mice. Con: Control, DSS: dextran sufate sodium salt and Data represents mean ± SEM, *𝑃<0.05, **𝑃<0.01.

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