The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury: Relationship with Nutritional Status

Figure 1

The impact of a single hemodialysis session on serum XOD activity. Serum xanthine oxidase activity (XOD) was determined prior to (pre-HD) and immediately after completion of hemodialysis session (post-HD) in patients with normal geriatric nutritional risk index (GNRI > 90) and with GNRI ≤ 90. In contrast to GNRI > 90 group, where a single HD session induced the fall of serum XOD activity from 19.3±10.6 U/L to 12.1±6.0 U/L (𝑃=0.002, paired samples 𝑡-test), in the group with GNRI ≤ 90, there was an elevation of serum XOD activity from 18.4±7.8 U/L to 24.8±7.3 U/L (𝑃=0.030, paired samples 𝑡-test), contributing to significant post-HD differences between GNRI groups (𝑃<0.001, independent samples 𝑡-test).