Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

Table 1

Gene orthology of NF-E2-related factor 2 across the species.

Species	Human; Homo sapiens	Cat; Felis catus	Chimpanzee; Pan troglodytes	Dog; Canis lupus familiaris	Cattle; Bos taurus
Official full name	nuclear factor (erythroid-derived 2)-like 2
Anthor name	nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2
Anthor name	HEBP1	—	—	—	—
Gene synonyms	NFE2L2, NRF2	NFE2L2, NRF2	NFE2L2, NRF2	NFE2L2, NRF2	NFE2L2, NRF2
Chromosome map	2q31.2	C1	2B	36	2
Genome sequence; (NCBI Build)	NC_000002.11; (GRCh37.p10)	NC_108730.1; (Felis_catus-6.2)	NC_006470.3; (Pan_troglodytes-2.1.4)	NC_006618.3; (CanFam3.1)	AC_000159.1; (Bos_taurus_UMD_3.1)
Primary source	HGNC: 7782	—	—	—	BOS_1716
Gene ID; mapping (orientation*)	4780; 178095031−178129859 (−)	101098812; 165356974−165392728 (−)	742622; 181721941−181756837 (−)	478813; 20989206−21021893 (−)	497024; 19659540−19692048
Ensemble gene ID; (mapping)	ENSG00000116044; (178092323−178257425)	—	ENSPTRG00000012677; (181721949−181756285)	ENSCAFG00000013506; (20987569−21022230)	ENSBTAG00000019255; (19659540−19692048)
RefSeq ID, mRNA size	NM_006164.4; (GI: 372620346), 2859 bp	XM_003990893.1; (GI: 410968909), predicted, 2394 bp	XM_001145876.2; (GI: 332814815), predicted, 2850 bp	XM_535975.3; (GI: 345797173), predicted, 2570 bp	NM_001011678.2; (GI: 147904941), 2409 bp
Protein ID (aa/MW^§)	NP_006155.2; (605/67696)	XP_003990942.1; (606/67797)	XP_001145876.2; (605/67686)	XP_535975.1; (601/67087)	NP_001011678.2; (607/67813)
UniProt ID	Q16236	—	A2T6Y9	—	Q5NUA6.2
Variants^#	14 transcripts, 12 isoforms	3 transcripts, 3 isoforms	5 transcripts, 5 isoforms	2 transcripts, 2 isoforms	—
Homology% gene/protein	100/100	89.3/91.4	99.9/99.9	89.3/88.8	90.5/89.1
Species	Rhesus monkey; Macaca mulatta	Chicken; Gallus gallus	Zebrafish; Danio rerio	Mouse; Mus musculus	Rat; Rattus norvegicus
Official full name	nuclear factor (erythroid-derived 2)-like 2			nuclear factor, erythroid-derived 2, like 2
Anthor name	nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2
Anthor name	HEBP1	—	—	—	—
Gene synonyms	NFE2L2, NRF2, Mmu.966	NFE2L2, NRF2	nfe2l2, Nrf2, Nrf2a, wu:fc15g09, wu:fj67e03	Nfe2l2, Nrf2, AI194320	Nfe2l2, Nrf2
Chromosome map	12	7	9	2C3; (44.75 cM)	3q23
Genome sequence; (NCBI Build)	NC_007869.1	NC_006094.3	NC_007120.5; (Zv9)	NC_000068.7; (GRCm38.p1)	NC_005102.3; (Rnor_5.0)
Primary Source	—	CGNC: 49604	ZFIN: ZDB-GENE-030723-2	MGI: 108420	RGD: 620360
Gene ID mapping (orientation*)	707606; 40848940−40884600 (−)	396014; 15304546−15320356	360149; 1643746−1670288	18024; 75675519−75704641 (−)	83619; 69041647−69069070 (−)
Ensemble gene ID; (mapping)	ENSMMUG00000001861; (40848948−40884174)	ENSGALG00000009240; (16897956−16922637)	ENSDARG00000042824; (1643631−1672715)	ENSMUSG00000015839; (75675513−75704641)	ENSRNOG00000001548; (58366693−58394118)
RefSeq ID, mRNA size	NM_001257607.1; (GI: 383872375), 2335 bp	NM_205117.1; (GI: 45384113), 2555 bp	NM_182889.1; (GI: 33504557), 2149 bp	NM_010902.3; (GI: 76573877), 2469 bp	NM_031789.2; (GI: 402692377), 2305 bp
Protein ID; (aa/MW^§)	NP_001244536.1; (606 /67703)	NP_990448.1; (582/65160)	NP_878309.1; (586/65757)	NP_035032.1; (597/66770)	NP_113977.1; (597/66825)
UniProt ID	F7GPD8	Q90834	Q8JIM1	Q60795	O54968
Variants^#	2 transcripts, 2 isoforms	1 transcript, 1 isoform	1 transcript, 1 isoform	1 transcript	1 transcript, 1 isoform
Homology% gene/protein	98.8/99.0	72.6/67.4	54.6/49.1	83.4/82.5	83.8/83.2

Refer to http://www.ncbi.nlm.nih.gov/homologene/2412 and reference [14] for cross-species homology. Details of homology scores and sequences can be also obtained by blast against human sequence (http://blast.ncbi.nlm.nih.gov).#Further information on transcript variants and protein isoforms are viewable by gene ID at NCBI (http://www.ncbi.nlm.nih.gov/refseq/rsg) and e!Ensemble (http://useast.ensembl.org/index.html) or by protein ID at UniProt (http://www.uniprot.org). §MW: predicted molecular weight from NCBI (MW in UniProt varies slightly.). RefSeq: reference sequence, aa: amino acids, and ∗gene in complement orientation.