NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

Table 1

The basal levels of the Nrf2 and Nrf2-targeted genes in the “graded Nrf2 activation” model.

	Nrf2-null	Wild-type	Keap1-Kd	Keap1-HKO
Nrf2-related
Nqo1	0.037 ± 0.007*	0.29 ± 0.02	0.74 ± 0.12*	3.17 ± 0.36*
Nrf2	0.002 ± 0.001*	0.07 ± 0.02	1.46 ± 0.05*	2.10 ± 0.24*
Gclc	3.84 ± 0.86*	7.01 ± 1.11	10.1 ± 1.37*	27.2 ± 2.49*
GSH-related
Gsr	0.11 ± 0.01*	0.21 ± 0.01	0.03 ± 0.01	0.06 ± 0.01*
Gsta1	0.45 ± 0.11*	2.77 ± 1.43	15.4 ± 3.58*	51.1 ± 7.25*
Gsta4	1.48 ± 0.39*	2.97 ± 1.14	4.63 ± 1.02	7.93 ± 1.55*
Gstmu	20.7 ± 1.43*	107 ± 28.3	544 ± 98.2*	1547 ± 350*
Gstpi	101 ± 22.2	7.01 ± 1.11	10.1 ± 1.37*	27.2 ± 2.49*
Gpx2	0.02 ± 0.01	0.04 ± 0.03	0.06 ± 0.01	2.15 ± 0.81*
Acute-phase
Mt-1	4.22 ± 0.93	3.48 ± 1.11	20.1 ± 5.43*	27.4 ± 2.49*
Ho-1	0.46 ± 0.06	0.64 ± 0.03	0.87 ± 0.15*	1.23 ± 0.37*

Data are % of the housekeeping gene G3PDH and represent mean ± SEM of serum ALT values (𝑛=6–10), *significantly different from wild-type mice, 𝑃<0.05.