Mitochondrial-Targeted Two-Photon Fluorescent Probes for Zinc Ions, , and Thiols in Living Tissues
Scheme 1
(a) Comparison of one- and two-photon exited fluorescence; the fluorescence is emitted upon excitation by one-photon of higher energy and two-photons of lower energy, respectively. (b) Design of the mitochondria-targeted two-photon probes. Mitochondrial targeting moiety (TPP) and receptors for the analytes are linked to the opposite ends of the fluorophore. (c) Chemical structures of the mitochondrial-targeted two-photon probes for Zn2+ (SZn-Mito and SZn2-Mito), H2O2 (SHP-Mito), and thiols (SSH-Mito).
