Reactive Oxygen Species in Vascular Formation and Development
Figure 5
Signaling pathways in ROS-mediated SMC migration activated by agonists. Various agonists such as AngII, PDGF and thrombin activate c-Src in a ROS-dependent way. Signaling cascades downstream of c-Src include EGFR transactivation followed by PI3K/AKT or ERK activation (for AngII) (a) and direct PDK1/PAK phosphorylation (for PDGF) (b). Basic fibroblast growth factor (bFGF) activates PKC and Rac instead of c-Src in smooth muscle cells, but the ultimate JNK or PI3K/Akt activation still requires Nox-derived ROS.
