Reactive Oxygen Species in Vascular Formation and Development

Figure 6

Regulation of slingshot-cofilin pathway by reactive oxygen specious in SMCs. Cofilin is phosphorylated and inactivated by LIM kinase, and p-cofiln is dephosphorylated and activated by phosphatase slingshots-1L. SSHL is sequestered by a regulatory protein 14-3-3. Increasing level of ROS oxidizes 14-3-3, releasing SSH1L phosphatase, which, on the one hand, dephosphorylates other SSH1L molecules to increase SSH1L phosphatase activity. On the other hand, SSH1L dephosphorylates cofilin, which recycles actin monomers for cytoskeletal remodeling during smooth muscle cell migration.