Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques

Table 2

Levels of protein-bound and total LMW-thiols from stable and unstable plaque extracts.

	Stable (nmol/g prot)	Unstable (nmol/g prot)	P value
Protein-bound LMW-thiols
Cys-Gly	13.2 (11.3–16.9)	12.1 (8.4–17.1)	0.339
Hcy	5.7 ± 3.2	6.7 ± 4.0	0.468
Cys	146.0 (117.5–211.4)	219.6 (147.6–301.9)	0.089
GSH	41.1 (23.2–77.9)	80.8 (42.0–122.1)	0.168
Glu-Cys	14.1 ± 5.6	15.3 ± 7.0	0.593
Total	283 ± 126	373 ± 111	0.034
Total LMW-thiols
Cys-Gly	53.8 ± 21.1	44.6 ± 19.7	0.205
Hcy	15.0 ± 10.2	20.7 ± 12.3	0.179
Cys	600 ± 276	576 ± 208	0.767
GSH	128.6 (95.1–202.4)	171.2 (97.2–346.4)	0.189
Glu-Cys	69.2 ± 29.4	62.7 ± 29.8	0.534
Total	900 ± 273	960 ± 293	0.555

Values are either mean ± SD or median with ranges (in parenthesis).
LMW-thiols levels were expressed as nmol/g of extracted proteins.
Total LMW-thiols are the sum of free LMW-thiols and protein-bound LMW-thiols.