Oxidative Stress and Free-Radical Oxidation in BCG Granulomatosis Development
Table 1
Numerical density and cellular composition of BCG granulomas in the liver and lungs of BCG-infected mice.
Parameter
Liver
Lungs
Time after infection (days)
30
60
90
30
60
90
Numerical density of granulomas (Nai), 3.64 × 105 m2
3.08 ± 0.26
7.84 ± 0.64#
8.36 ± 0.54
7.40 ± 0.57
8.24 ± 0.51
11.24 ± 0.46#
Diameter of granulomas, m
47.25 ± 1.26
53.18 ± 1.54#
58.92 ± 1.32#
49.69 ± 1.24
68.71 ± 0.34#
71.12 ± 1.82
Macrophage number, %$
65.12 ± 0.69
33.85 ± 0.87#
14.72 ± 1.33#
47.94 ± 0.53
27.11 ± 0.86#
23.13 ± 0.59#
Epithelioid cell number, %$
22.56 ± 0.87
57.05 ± 0.89#
77.35 ± 1.42#
26.37 ± 0.23
52.21 ± 1.04#
58.21 ± 0.23#
Neutrophil number, %$
2.47 ± 0.18
0.69 ± 0.14#
0.21 ± 0.09#
1.83 ± 0.23
2.53 ± 0.49
2.09 ± 0.42
Lymphocyte number, %$
7.51 ± 0.30
5.47 ± 0.20#
1.64 ± 0.27#
12.48 ± 1.21
7.19 ± 0.36#
3.92 ± 0.31#
Fibroblast number, %$
2.34 ± 0.20
2.94 ± 0.18#
6.08 ± 0.24#
11.38 ± 0.31
10.96 ± 0.36
12.65 ± 0.81#
The results represent the mean ± SEM.
$100%: the total number of cells in granuloma. #The value significantly differs from the value for the previous observation period ( < 0.05).
