The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells
Figure 1
Chemical structures of modified NSAIDs and their traditional NSAID precursors. Phosphosulindac, which exemplifies phospho-NSAIDs, consists of the sulindac molecule linked at the –COOH site to a phosphate group via an aliphatic spacer molecule (both shown in green). In the HS-NSAID known as HS-ibuprofen, an aromatic spacer molecule links an H2S-releasing dithiolethione group (both shown in red) to the ibuprofen structure. Similarly, the NO-NSAID NO-aspirin is composed of an NO-releasing-NO2 group and an aromatic spacer molecule (both shown in blue) which is linked to the –COOH group of aspirin. Finally, the modified NSAID chimera known as NOSH-aspirin is characterized by the aspirin structure linked via two separate spacer molecules to both a H2S-releasing moiety (shown in red) and an NO-releasing moiety (shown in blue).
