Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase
Figure 6
The diagrams show the effect of HO inhibition by tin protoporphyrin (SnPP) on the decrease in heart perfusion (a) expressed as the percentage of change, measured by incubation liquid given AVP (1.0, 3.0, 10.0 μg) in hearts of male (the black square) and female (the grey square). The Panel (b) demonstrates effect of the HO inhibitor tin protoporphyrin (SnPP) on ST segment changes (measured in a lead II standard surface ECG; expressed in mV) following intravenous injection of epinephrine (10.0 μg/kg) and 30 s later phentolamine (15.0 mg/kg). White columns (the white square) show the intact groups without SnPP treatment. Patterned columns show the actions of SnPP (30.0 mg/kg pretreatment 24 hours and one hour prior to the measurement). Results are shown as means ± S.E.M. for 10 animals in each group. Statistical significance: as compared to the ovary intact group and a significant difference between groups with and without SnPP pretreatment.
