Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

<table>The electron transport chain (ETC) responsible for ATP and ROS production in mitochondria. ROS: reactive oxygen species, TCA: tricarboxylic acid, NADH &amp; NAD<sup>+</sup>: nicotinamide adenine dinucleotide reduced form &amp; oxidized form, FADH2 &amp; FAD; flavin adenine dinucleotide reduced form and oxidized form, ADP: adenosine diphosphate, ATP: adenosine triphosphate, Co Q: coenzyme Q, Cyt c: cytochrome c, UCP: uncoupling protein. </table>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins 