Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

Figure 2

PKCβ plays a key role in adipogenesis and obesity. Excess glucose increases ROS levels that lead to PKCβ activation, and this activation is required in the induction of adipogenesis and consequently in the increasing of obesity risk. APDs influence adipogenic events by PKCβ activation, and its inhibition through hispidine could prevent or delay the development of obesity.