Review Article
Pituitary Adenoma Nitroproteomics: Current Status and Perspectives
Table 1
Nitroprotein and unnitrated protein identified from pituitary adenoma [
4] and control tissue [
3,
16].
| Protein name | nY site |
| Pituitary adenoma |
| Nitrated protein | | Rho-GTPase-activating 5 Q13017 (ARHGAP5) | Y550 | Leukocyte immunoglobulin-like receptor A4 P59901 | Y404 | Zinc finger protein 432 O94892 | Y41 | PKA-beta regulatory subunit [P31321] (PRKAR1B) | Y20 | Sphingosine-1-phosphate lyase 1 O95470 | Y356 |
Y366 | Centaurin-beta 1 [Q15027] | Y485 | Proteasome subunit alpha type 2 [P25787] (PSMA2) | Y228 | Interleukin 1 family member 6 [Q9UHA7] (IL1F6) | Y96 | Rhophilin 2 [Q8IUC4] (RHPN2) | Y258 | Nitroprotein-interacted protein | | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) O43187 (IRAK2) | | Glutamate receptor-interacting protein 2 [Q9C0E4] (GRIP2) | | Ubiquitin [P629881] (UBB or UBC) | |
| Pituitary control |
| Nitrated protein | | Synaptosomal-associated protein (SNAP91) | Y237 | Ig alpha Fc receptor [P24071] (FCAR) | Y223 | Actin [P03996] (ACTA2, ACTG2, and ACTC1) | Y296 | PKG 2 [Q13237] (PRKG2) | Y354 | Mitochondrial cochaperone protein HscB [Q8IVVL3] | Y128 | Stanniocalcin 1 [P52823] (STC1) | Y159 | Proteasome subunit alpha type 2 (PSMA2) | Y228 | Progestin and adipoQ receptor family member III [Q6TCH7] (PAQR3) | Y33 |
|
|
nY: nitrotyrosine. Modified from Zhan and Desiderio [3, 4, 16], with permission from Elsevier Science, copyright 2004, 2006, and 2007.
|