Neurotoxic Effects of trans-Glutaconic Acid in Rats

Table 1

In vitro effect of trans-glutaconic acid (tGA) on creatine kinase (CK), respiratory chain complex IV, and ATP synthase activities in cerebral cortex of 30-day-old rats.

Group	CK	Complex IV	ATP synthase
Control	11.28 ± 0.20	114.72 ± 7.42	476.00 ± 31.23
0.1 mM tGA	10.66 ± 0.78	116.46 ± 2.57	—
1 mM tGA	11.04 ± 1.18	107.14 ± 3.29	508.75 ± 15.47

The experiments were performed in triplicate, and data represent mean ± standard error of the mean (𝑛 = 4-5). It was not observed any difference among groups (ANOVA and Student' t-test). CK: μmol · min⁻¹ · mg of protein⁻¹; complex IV and ATP synthase: nmol · min⁻¹ · mg of protein⁻¹.