ALS and Oxidative Stress: The Neurovascular Scenario

Figure 2

Role of hypoperfusion in elevation of oxidative stress and energy failure. As hypoperfusion reduces blood flow towards cells resulting in reduced ferritin Fe³⁺ protein, it releases unbound iron Fe²⁺ molecules resulting in formation of ROS thus increasing the oxidative stress. Hypoperfusion also leads to unavailability of glucose to brain cells thus leading to energy failure.