ALS and Oxidative Stress: The Neurovascular Scenario

Figure 4

VEGF and permeability of blood brain barrier. Astrocytic expression of HIF-alpha and VEGFA leads to downregulation of claudins CLN-5 and their regulatory protein OCLN. VEGFA, by the virtue of tyrosine phosphorylation, downregulates the expression of CLN ultimately resulting in disruption of permeability barrier. VEGF induces the migration among the endothelial cells and increases the permeability to CNS.