Enhanced Prostacyclin Synthesis by Adenoviral Gene Transfer Reduced Glial Activation and Ameliorated Dopaminergic Dysfunction in Hemiparkinsonian Rats

Figure 3

CAY10449 and AdPGIS transduction on MTT reduction in mixed glial cultures. CAY10449 is a high affinity ligand and functional antagonist for the human IP (prostacyclin) receptor. CAY10449 (500 nM) was added to cultured cells at 2 hr after AdPGIS transduction. Data were means ± SEM from 4 independent cultures done in duplicate. ^a𝑃<0.01 AdPGIS versus Control; ^b𝑃<0.05 AdPGIS + CAY10449 versus AdPGIS.