Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies

Table 1

TBARS, nitrites, and cysteine levels from serum and red blood cells obtained from control subjects and from patients with type 2 DM and/or cirrhosis.

Parameter	Healthy (𝑛=60)	Diabetes (𝑛=60)	Cirrhosis (𝑛=70)	Diab + Cirrhos (𝑛=25)
Serum TBARS	0.35 ± 0.13	0.40 ± 0.10	0.37 ± 0.09	0.42 ± 0.18
RBC TBARS	0.42 ± 11	0.62 ± 0.08*	1.15 ± 0.35*	0.84 ± 0.35^*,***
RBC/serum ratio	1.20 ± 0.34	1.55 ± 0.29*	3.11 ± 0.89*	2.00 ± 0.78*
Serum nitrites	26 ± 3	37 ± 8	63 ± 25*	46 ± 18*
RBC nitrites	32 ± 6	68 ± 7*	150 ± 47*	62 ± 24*
RBC/serum ratio	1.2 ± 0.2	1.8 ± 0.3*	2.3 ± 0.9*	1.4 ± 0.4
Serum cysteine	18 ± 4	44 ± 12*	28 ± 9*	39 ± 15*
RBC cysteine	23 ± 7	37 ± 10	153 ± 52*	87 ± 34^*,***
RBC/serum ratio	1.3 ± 0.3	0.8 ± 0.2	5.3 ± 1.8*	2.2 ± 0.9^*,***

Results are expressed as mean ± SD of determinations done in blood samples membranes from controls (𝑛=60), patients with type 2 DM (𝑛=60), cirrhotic patients (𝑛=70), and diabetic patients with cirrhosis (𝑛=25). RBC: red blood cells. Statistical significance: *𝑃<0.01, versus control; **𝑃<0.01, versus DM or versus cirrhosis; ***𝑃<0.01, versus both the diabetes and cirrhosis groups, separately.