Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies

Table 2

Levels of phospholipids and cholesterol in RBC membranes obtained from control subjects and from patients with type 2 DM and/or cirrhosis.

Parameter	Healthy (𝑛=60)	Diabetes (𝑛=60)	Cirrhosis (𝑛=70)	Diab + Cirrhos (𝑛=25)
PS (nmoles/mg)	40±14	34±10	30±8^∗	63±14^∗,∗∗∗
PI (nmoles/mg)	46±10	45±11	50±12	126±26^∗,∗∗∗
PC (nmoles/mg)	62±14	63±16	77±17^∗	194±36^∗,∗∗∗
PE (nmoles/mg)	23±6	27±6	26±6	70±10^∗,∗∗∗
Cholesterol (nmoles/mg)	17±4	18±5	25±6^∗	41±6^∗,∗∗∗

Results are expressed as mean ± SD of determinations done in RBC membranes from controls (𝑛=60), patients with type 2 DM (𝑛=60), cirrhotic patients (𝑛=70), and diabetic patients with cirrhosis (𝑛=25). PC: phosphatidylcholine; PE: phosphatidylethanolamine; PI: phosphatidylinositol; PS: phosphatidylserine; Diab + Cirrhos: diabetes + cirrhosis. Statistical significance: *𝑃<0.01, versus control; **𝑃<0.01, versus DM or versus cirrhosis; ***𝑃<0.01, versus both the diabetes and cirrhosis groups, separately.