Neuroprotective Function of DJ-1 in Parkinson’s Disease

Figure 4

Schematic model of activation of the tyrosine hydroxylase gene by DJ-1. In the absence of DJ-1, PSF binds to the promoter region spanning −2909 to −2707 of the tyrosine hydroxylase (TH) gene to repress its transcription. In the presence of DJ-1, DJ-1 binds to PSF to sequester PSF from the TH gene, resulting in replacement of the corepressor complex with a coactivator complex, thereby activating TH gene transcription.