Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
Figure 2
Effect of DDC on AmB-tolerant cells in biofilms of C. albicans clinical isolates F17, G6, and 2CA. C. albicans biofilms of F17, G6, or 2CA were treated with or without (/) 1 μM AmB in presence or absence (−) of 10 mM DDC. Afterwards, biofilms were washed with PBS and survival of Candida cells was determined by plating the biofilm cells on YPD plates. The AmB-tolerant fraction in presence or absence of 10 mM DDC was determined relative to DMSO treatment. Data represent the mean and SEM for one representative experiment out of two, each consisting of triplicate measurements. F16 (white bars), G6 (black bars), 2CA (grey bars). **; ***.
