Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?

Table 3

Effects of calorie restriction or starvation on Sirt1 in different tissues in mice and rats.

Species	Number animals	Caloric restriction	Tissue	Outcome	Reference
Mice (C57BL6)	10	40%	Muscle, fat; liver	Sirt1 ↑; (protein); Sirt1  ↓; (protein)	[66]
Mice; (C57BL/6×C3H/He F1 hybrid)	4	15%	Brain, liver; heart, muscle	No  effect on  Sirt1 (protein); Sirt1  ↓; (protein)	[13]
Mice; (C57BL6)	—	24 h starvation	Liver	Sirt1 ↑; (protein); no  effect on mRNA	[65]
Mice; (C57BL)	—	24 h starvation	Brain,  heart, muscle,  white  adipose  tissue, and kidney	Sirt1 ↑; (protein); no  effect on mRNA	[70]
Mice; (C57BLK/6×SV127 F1 hybrid)	10	30–40%	White  adipose tissue	Sirt1 ↑; (protein)	[36]
Mice; (C57BL6)	—	40%	White  adipose tissue, liver, kidney, and brain	Sirt1 ↑; (protein); not significant	[71]
Rats; (Fisher 344)	—	40%	Brain,  fat,  kidney, and liver	Sirt1 ↑; (protein)	[57]