The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

Table 1

Clinical EAE parameters in WT and p66Shc−/− mice.

Strain	Disease onset (day 10) score	Disease onset (day 13) score	Number of mice with score ≥3	Mean maximum score	AUC (days)
WT	1.80±0.3	2.20±0.34	3/5	3.20±0.50	21.95±3.54
P66Shc−/−	0	1.00±0.43	2/5	2.5±0.62	13.65±4.91

Data are mean of three independent experiments ± SE. (AUC: area under the curve) values are calculated at day 20 from the immunization.