Research Article
The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration
Table 2
Clinical EAE parameters in WT, Cyc-D−/−, and p66Shc/Cyc-D−/− mice.
| | Strain | Disease onset
(day 11) score | Disease onset
(day 13) score | Survival at sacrifice
Day 27 | Number of mice
with score ≥3 | Day of maximal
score | Mean maximum
score | AUC (days) |
| | WT | 0.75 ± 0.33 | 2.45 ± 0.18 | 3/10 | 10/10 | 20 | 4.7 ± 0.21 | 22.10 ± 2.91 | | Cyc-D−/− | 0 | 2.08 ± 0.30 | 6/6 | 4/6 | 14 | 3.17 ± 0.31 | 26.83 ± 2.55 | | P66Shc/Cyc-D−/− | 0 | 1.14 ± 0.37 | 6/7 | 5/7 | 21 | 3.85 ± 0.35 | 23.50 ± 2.24 |
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Data are mean three independent experiments ± SE. Values are calculated at day 20 from the immunization.
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