Review Article

The Benefits of Humanized Yeast Models to Study Parkinson’s Disease

Figure 1

Expression of α-synuclein and synphilin-1 in Saccharomyces cerevisiae. (a) Fluorescence microscopic visualization of wild type α-synuclein-eGFP (left panels) and dsRed-synphilin-1 (right panels) fusion proteins expressed separately in wild type yeast cells. (b) and (c) Quantification of viable cells (b) and DHE positive cells (c) in wild type yeast cells expressing wild type α-synuclein and synphilin-1 alone or together. The strains were kept in culture for two weeks [24].
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