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Oxidative Medicine and Cellular Longevity
Volume 2013 (2013), Article ID 796891, 14 pages
http://dx.doi.org/10.1155/2013/796891
Review Article

Site-Specific Antioxidative Therapy for Prevention of Atherosclerosis and Cardiovascular Disease

Second Department of Internal Medicine, Kansai Medical University, Moriguchi City 570-8507, Japan

Received 26 February 2013; Accepted 9 April 2013

Academic Editor: Mahesh Thirunavukkarasu

Copyright © 2013 Hajime Otani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxidative stress has been implicated in pathophysiology of aging and age-associated disease. Antioxidative medicine has become a practice for prevention of atherosclerosis. However, limited success in preventing cardiovascular disease (CVD) in individuals with atherosclerosis using general antioxidants has prompted us to develop a novel antioxidative strategy to prevent atherosclerosis. Reducing visceral adipose tissue by calorie restriction (CR) and regular endurance exercise represents a causative therapy for ameliorating oxidative stress. Some of the recently emerging drugs used for the treatment of CVD may be assigned as site-specific antioxidants. CR and exercise mimetic agents are the choice for individuals who are difficult to continue CR and exercise. Better understanding of molecular and cellular biology of redox signaling will pave the way for more effective antioxidative medicine for prevention of CVD and prolongation of healthy life span.