817807.fig.001
Figure 1: Schematics of the pathogenic mechanism of familial and sporadic α-synucleinopathies. Loss of function of the PINK1-Parkin pathway may be causative in the mitochondrial dysfunctions of some familial PD, while gain of functions of α-synuclein and LRRK2 may play a central role in the pathogenesis of sporadic PD.