The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury

Figure 2

Covalent modification of Keap1 cysteine residues by electrophiles. The BTB, IVR, and DC domains are essential for the formation of homodimers, associated with cullin 3 and the binding of Nrf2. 1,2-NQ: 1,2-naphthoquinone; TBQ: tert-butyl-1,4-benzoquinone.