The CHAOS study is the largest study to report a strong decrease in nonfatal MI but, conversely, a slight increase in cardiovascular death. Other studies were performed in smaller groups. Overall, no overwhelming positive effects could be found in the studies. Population*: : number of patients; M: male; F: female; y: age in years. DB: double blind; PC: placebo controlled; d: days; m: months; E: vitamin E; C: vitamin C; NAC: N-acetylcysteine; PUFAn-3: polyunsaturated fatty acids n-3; EPA: eicosapentaenoic; DHA: docosahexaenoic; γOZ: γ-oryzanol; I: incidence; BP: blood pressure; CV: cardiovascular; MI: myocardial infarction; HT: hypertension; AMI: acute myocardial infarction; OS: oxidative stress.