Ulinastatin Suppresses Burn-Induced Lipid Peroxidation and Reduces Fluid Requirements in a Swine Model

Table 1

Hemodynamic variables in MAP, CO, ELWT, and PVPI.

Variables	After injury (h)
	0	6	12	18	24	36	48
MAP (mm Hg)
Group ILR	90.5 ± 6.5	90.2 ± 5.8^c	93.6 ± 6.3	91.2 ± 6.1	92.3 ± 6.5	92.6 ± 6.4	96.2 ± 4.9
Group ILR/ULI	89.3 ± 4.4	93.2 ± 6.4^d	94.6 ± 5.5	94.2 ± 6.3	93.3 ± 5.2	90.1 ± 4.3	94.0 ± 3.3
Group DLR	91.1 ± 6.6	75.2 ± 3.4	89.2 ± 5.3	96.0 ± 6.2	92.0 ± 5.3	96.3 ± 6.9	93.8 ± 6.8
Group DLR/ULI	90.7 ± 5.3	73.2 ± 4.6	90.6 ± 4.5	91.0 ± 5.7	95.0 ± 5.9	95.1 ± 6.8	94.5 ± 5.5
CO (L·min^−1)
Group ILR	3.76 ± 0.43	3.66 ± 0.38^c	3.39 ± 0.46^c	3.61 ± 0.34^c	3.88 ± 0.49^c	3.78 ± 0.45	3.79 ± 0.47
Group ILR/ULI	3.69 ± 0.44	3.70 ± 0.39^d	3.55 ± 0.36^d	3.58 ± 0.35^d	4.06 ± 0.69	3.87 ± 0.52	3.83 ± 0.57
Group DLR	3.89 ± 0.53	2.66 ± 0.35	2.87 ± 0.40	2.86 ± 0.35	3.07 ± 0.36	3.35 ± 0.45	3.69 ± 0.50
Group DLR/ULI	3.76 ± 0.45	2.70 ± 0.38	3.05 ± 0.28	3.18 ± 0.33^b	3.66 ± 0.28^b	3.67 ± 0.41	3.80 ± 0.49
ELWI (mL·kg^−1)
Group ILR	8.13 ± 0.64	11.17 ± 1.15^c	11.65 ± 1.54	10.05 ± 1.09^c	9.98 ± 0.87	9.56 ± 1.05	9.23 ± 0.56
Group ILR/ULI	8.02 ± 0.62	11.38 ± 1.24^d	10.22 ± 0.98^a	9.46 ± 1.07	9.23 ± 0.85^a	8.76 ± 0.95^a	8.48 ± 0.63^a
Group DLR	8.15 ± 0.81	13.02 ± 0.86	12.55 ± 1.05	11.89 ± 1.12	10.26 ± 0.57	9.84 ± 0.67	9.68 ± 0.76
Group DLR/ULI	8.14 ± 0.69	13.26 ± 1.04	11.18 ± 0.78^b	10.06 ± 0.75^b	9.12 ± 0.60^b	8.86 ± 0.54^b	8.55 ± 0.57^b
PVPI
Group ILR	2.71 ± 0.26	3.31 ± 0.37^c	3.78 ± 0.30	3.87 ± 0.37	3.82 ± 0.29	3.68 ± 0.35	3.25 ± 0.31
Group ILR/ULI	2.58 ± 0.25	3.28 ± 0.25^d	3.32 ± 0.29^a	3.13 ± 0.34^a	3.01 ± 0.33^a	2.98 ± 0.21^a	2.90 ± 0.29^a
Group DLR	2.57 ± 0.24	4.29 ± 0.51	3.99 ± 0.27	3.78 ± 0.32	3.67 ± 0.34	3.64 ± 0.18	3.44 ± 0.31
Group DLR/ULI	2.68 ± 0.18	4.11 ± 0.14	3.50 ± 0.26^b	3.24 ± 0.11^b	3.17 ± 0.29^b	3.02 ± 0.35^b	2.75 ± 0.23^b

MAP: mean arterial pressure, CO: cardiac output, ELWI: extravascular lung water index, PVPI: pulmonary vascular permeability index. Data were expressed as mean ± SD. 𝑛= 7–10 per time point. ^aULI versus ILR; ^bDLR/ULI versus DLR; ^cILR versus DLR; and ^dILR/ULI versus DLR/ULI at 𝑃<0.05.