Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation
Figure 5
Th17 and IL-17 trend higher in spleen and grafts, respectively, from Nrf2 KO recipients. Flow cytometry analysis of spleens from recipient mice (Nrf2 WT, KO, or WT + SF) at day 2 (2 d) after transplantation shows a trend toward increased Th17 cells in the KO group (a). This is supported by notably higher expression of IL-17 mRNA in grafts isolated from Nrf2 KO recipients at 2 days (b), with no differences between groups at 5 days.
