Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation

Table 3

Sulforaphane pretreatment delays graft rejection.

	WT day 2; (grade 𝑁/total 𝑁)	KO day 2; (grade 𝑁/total 𝑁)	WT + SF day 2; (grade 𝑁/total 𝑁)	WT day 5; (grade 𝑁/total 𝑁)	KO day 5; (grade 𝑁/total 𝑁)	WT + SF day 5; (grade 𝑁/total 𝑁)
No rejection	1/5	2/3	5/5
Grade 1R	1/5	1/3		1/4	1/4
Grade 2R	3/5			3/4	3/4	3/3
Quilty				4/4

𝑁 = 3–5 animals for each group. Data is displayed as “𝑁”—meeting histological criteria/total analyzed “𝑁.” Heart sections were formalin fixed and paraffin embedded prior to being stained with H&E for histology analysis. Definition of terms: 1R = mild, focal perivascular and/or interstitial infiltrate without myocyte damage, 2R = medium, multifocal infiltrate with myocyte damage, “Quilty”: inflammation from the outside-in, that is, starting from the epicardium, possibly due to infection rather than rejection.