Phytoagents for Cancer Management: Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms

Figure 2

Markers of oxidative DNA damage are elevated in cancer patients. ROS causes oxidative damage to biomolecules such as DNA, lipids, and proteins, and the resulting end products are often detrimental to normal cell physiological functions. As the result of DNA base oxidation, 8-oxo-guanine (8-oxoG) can serve as a biomarker of primary oxidative DNA damage. When lipids are attacked by ROS, secondary DNA damage arises due to malondialdehyde (MDA), the end production of lipid peroxidation that can covalently bind to guanine and form MDA-DNA adduct (M1dG). In human cancer patients, both 8-oxoG and M1dG are found to be elevated, suggesting a correlation between higher oxidative stress and cancer.