Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats

Table 1

Effect of Clonidine treatment on TBARS, PCO, TAS, and NO level of Clonidine treated and untreated WKY and WKY administered L-NAME.

Parameters	Groups
	WKY	WKY+L-NAME	WKYC	WKYC+L-NAME
TAS	7.64 ± 0.17	6.91 ± 0.05	10.54 ± 0.93 a***	8.53 ± 0.18
TBARS	5.59 ± 0.32	7.49 ± 0.20 b***	7.80 ± 0.49 a*	8.98 ± 0.25 c*
PCO	2.69 ± 0.07	3.12 ± 0.05 b***	2.94 ± 0.18	3.11 ± 0.19 c*
NO	37.65 ± 0.56	27.92 ± 0.79 b***	39.25 ± 0.65	30.71 ± 0.69 d***

Values are expressed as mean ± S.E.M. (𝑛=6 per group).
WKY: WKY no treatment, WKY+L-NAME: WKY no treatment+L-NAME, WKYC: WKY+Clonidine, and WKYC+L-NAME: WKY+Clonidine+L-NAME.
a*  P < 0.05, a***  P < 0.001 WKY compared to WKYC, b***  P < 0.001 WKY+L-NAME compared to WKY, c*  P < 0.05 WKYC+L-NAME compared to WKY+L-NAME, and d***  P < 0.001 WKYC+L-NAME compared to WKYC.