Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase
Figure 1
Metabolic positioning of Tkl1p and Hem12p. (a) Transketolase (Tkl1p) catalyses a number of reactions in the PPP, linking energy metabolism, antioxidant response, and biosynthesis of nucleic acids and aromatic amino acids. (b) Uroporphyrinogen decarboxylase (Hem12p) catalyses the 5th step in heme biosynthesis before biosynthesis is completed within mitochondria. Heme biosynthesis is closely linked to oxygen tension and iron homeostasis. ALA, 5-aminolevulinic acid; Urogen, Coprogen, and Protogen stand for uroporphyrinogen, coproporphyrinogen, and protoporphyrinogen, respectively. Other abbreviations are those usually employed for common metabolites.
