Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase

<table>MS analysis of recombinant Hem12p. (a) Representative extracted ion chromatograms (XIC) of peptide NNRDFFQTCR with Cys52 of Hem12p (a) reduced, (b) +GSSG, (c) +Grx2p system. Traces in the upper panels correspond to the reduced peptide followed by alkylation with NEM (+125); traces in red in the lower panel correspond to the peptide glutathionylated (+305). (d) Fragmentation spectra of the parent ion in reduced state (+NEM) and (e) with GSH are presented.</table>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase 

Figure 4 | Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase 