Review Article

Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion

Figure 3

Electron Microscopic Peroxidase-anti-Peroxidase immunocytochemical determination of the distribution of NOS1 immunolabeling features in control (a) and metastatic colorectal cancer liver tumor tissues (b)–(d). (a) NOS1 immunopositive EC (indicated by asterisk) were seen in control liver microvessels. Vacuoles are indicated by single arrow X4 000. (b) Tumor vessel endothelium (indicated by asterisk) showed no staining for NOS1 antibody. X20,000. (c) NOS1 immunopositive white blood cells (indicated by asterisk) were attached to vessel endothelium in tumor growth regions. X6,000. (d) NOS1 immunopositive myofibroblast (smooth muscle cell) were seen in metastatic liver tumor tissues. X10,000. Reprinted with permission of J Submicrosc Cytol Pathol [2].
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