Link between Cancer and Alzheimer Disease via Oxidative Stress Induced by Nitric Oxide-Dependent Mitochondrial DNA Overproliferation and Deletion
Figure 4
Ultrastructural labeling of inducible NOS (NOS2) immunoreactivity in metastatic liver tumor tissues that determined by using Pre-embedding Peroxidase-anti-Peroxidase Electron Microscopy Immunocytochemical techniques. (a) Tumor vessel EC was positively stained with NOS2. X8,000. (b) A high intensity of NOS2 immunopositive precipitate accumulated close to the luminal plasmalemma of the vascular EC in the tumor growth region. X8,000. (c) NOS2 immunopositive hepatocytes (asterisk). Lipid-contained areas of the hepatocytes (double arrow) were free from immunopositive reaction. X6,000. (d) NOS2 immunopositive myofibroblast-like cells (asterisk). X8,000. Reprinted with permission of J Submicrosc Cytol Pathol [2].